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GxP-Agent: Process-DAG Topology for Reliable Clinical Trial Programming with LLM Agents
arXiv:2608.16890v1 Announce Type: new Abstract: Clinical trial programming -- transforming study protocols into analysis-ready datasets under CDISC standards -- is a bottleneck in regulatory submissions, yet LLM-based code generation fails catastrophically on this task: across 11 single-shot attempts with five frontier models, none produces a valid subject-level analysis dataset. We introduce GxP-Agent, a multi-agent system that encodes regulatory process ordering as a directed acyclic graph (DAG), decomposing monolithic dataset generation into 15 domain-specific nodes executed by worker agents with pharmaverse skill context, validation gates, and conditional retry. On CDISC-Bench, a new execution-based benchmark built from the FDA pilot submission CDISCPilot01 (254 subjects, 49 ground-truth ADSL variables), GxP-Agent with Claude Sonnet 4.6 achieves 100% structural match (49/49 variables, 254 correct records) across three independent runs, compared to 59.2% for the best retrieval-augme
Proactive Road Safety Intervention in Australia: Predicting Risky Driving Hotspots from Connected Vehicle Data
arXiv:2608.16913v1 Announce Type: new Abstract: Road safety monitoring has historically been reactive, relying on crash-record analysis after fatalities and injuries have already occurred. Proactive identification of high-risk locations and dangerous driving behaviour before incidents occur is a critical but underexplored challenge. This paper addresses this gap using connected vehicle telemetry data from Greater Sydney, Australia, to detect and forecast near-miss risky driving events at the Local Government Area (LGA) level. Risky driving is quantified through g-force thresholds (hard braking >0.6g, harsh cornering >0.47g, harsh acceleration >0.5g), and spatio-temporal heatmaps are constructed to identify high-risk zones. Eight predictive models are benchmarked across three families: ensemble learning (Random Forests, XGBoost, LightGBM), deep learning (LSTM, N-BEATS), and classical time-series methods (ARIMA, Exponential Smoothing, Prophet). ARIMA achieves the lowest mean absolute err
VLCP: Vision Language Control Policy Closed-Loop Code Replanning for Robot Manipulation
arXiv:2608.16978v1 Announce Type: new Abstract: Turning a frontier vision-language model into a robot policy usually means fine-tuning it to emit an action representation it never saw in pretraining, which throws away much of the reasoning that made the model worth reaching for. We go the other way and keep the VLM frozen. It writes the policy as a short Python control function, with no demonstrations and no fine-tuning. Writing that code once is open-loop, though. Existing closed-loop methods react at the wrong level: they retry a fixed policy or pick a different subtask, but never rewrite the code that failed. VLCP closes the loop where the failure actually lives, on the control code, within a single episode. Every $K$ steps the VLM re-observes the scene from multi-view RGB, proprioceptive state, and a state delta, then rewrites the control function from what it just saw, so a failure is caught before it compounds. We evaluate on a 57-task MuJoCo/RoboVerse sweep. This training-free p
Runtime Governance for Agentic AI: Action-Boundary Control with Trusted Provenance and Fail-Closed Execution
arXiv:2608.16891v1 Announce Type: new Abstract: Agentic AI systems request tool actions that can modify files, send messages, launch jobs, or change workflow state. This shifts the safety problem from harmful text generation to harmful operational side effects. Prompt-level governance can shape model behavior, but it does not create an execution boundary. We introduce Aegis, a runtime governance system that treats model outputs as action proposals and mediates them through a trusted decision layer before tool execution. The model proposes; the trusted runtime decides. Aegis evaluates proposals against active policy state, resolves provenance server-side, fails closed under uncertainty, and routes selected cases through Senate-style settlement, a quorum- based non-unilateral authorization path. We evaluate Aegis on a repeated sandbox corpus spanning five run families, 42 tasks, three conditions, and ten repeats per family. Across 6,300 rows, prompt-policy conditioning produced 79 risky
Detecting and Discriminating Operator Misspecification in Hybrid PDE-Parameter Learning: a Reference-Free Instrument, with Discrimination Bounded In Sample
arXiv:2608.16925v1 Announce Type: new Abstract: We build an instrument that reads, from a single fit and with no oracle, whether the operator a hybrid PDE-parameter estimator postulates is wrong-and separates that from a merely unidentifiable parameter. On one self-adjoint parabolic inverse problem, an information-matrix statistic with plug-in scale and per-seed parameter has median 0.19 under correct specification, rejection rate $0.033$ against a pre-registered ceiling of $0.10$, and rises to $224$ and $85$ under two misspecifications, firing in every replicate. On a correctly specified but non-identifiable design it stays mute-$0.050$ at $n=200$, Clopper-Pearson $[0.024, 0.090]$-while a rank statistic collapses to zero at a pre-registered boundary $c_5^*=2.15\times10^{-3}.$ Two readings of one fit therefore separate the two failures across the three designs a deployable test reaches. That separation is the contribution; detection alone is a crowded flank. In sample it is a bound, ou
From Prototype to Production: The Architecture Behind Secure & Governed AI Agents
Building the Responsible AI, security, and governance layers required for enterprise-ready agents The post From Prototype to Production: The Architecture Behind Secure Governed AI Agents appeared first on Towards Data Science.
Building Enterprise Agent Systems that People can Trust, Verify and Improve
5 principles that determine whether an agent system succeeds in production, explained through one I built for a $100M+ company. The post Building Enterprise Agent Systems that People can Trust, Verify and Improve appeared first on Towards Data Science.
Graph Engineering Isn’t About More Connections — It’s About Which Ones Get Used
Adding more communication pathways between agents doesn’t necessarily improve multi-agent performance. In a controlled, reproducible experiment across 50 runs, recovery remained remarkably stable from 20% to 100% relationship density. But as the network became denser, the fraction of edges actually used fell sharply—revealing a gap between configured connectivity and behavioral connectivity. The post Graph Engineering Isn’t About More Connections — It’s About Which Ones Get Used appeared first on Towards Data Science.
Ten Is Not a Hundred
The number that fooled every hallucination detector The post Ten Is Not a Hundred appeared first on Towards Data Science.
How to Add Skills in Agents using LangChain
Ever wondered how ChatGPT, Gemini, and other chat interfaces generate PDFs, PowerPoints, and more when all they have under the hood is an LLM? The trick isn’t a smarter model. It’s something simpler: skills which are instructions an agent loads only when needed. Next, let’s explore how skills work using LangChain and how they can make [ ] The post How to Add Skills in Agents using LangChain appeared first on Analytics Vidhya.
Large Language Models Show Metacognitive Sensitivity in Medical Reasoning
arXiv:2608.14552v1 Announce Type: new Abstract: Large language models (LLMs) are increasingly evaluated and used in medicine, but clinical usefulness depends on answer accuracy and whether confidence tracks evidence quality and uncertainty. We developed a controlled, psychophysics-inspired clinical benchmark to test diagnostic choice and confidence behavior in a medical LLM. The benchmark focused on probable Alzheimer-type neurocognitive disorder (AT-NCD) versus depression-related cognitive impairment (DRCI). We generated 45 synthetic vignettes varying evidence strength, conflicting evidence, and missing information. Each vignette was presented under three prompt variants, yielding 135 trials. In a pilot run with gpt-4.1-nano, all trials produced valid structured outputs. Across forced-choice trials, diagnostic accuracy was 93.5%, mean confidence was 78.4%, and AUROC2 was 0.876. Confidence increased with evidence distance from the diagnostic boundary, decreased when information was mis
SpotlessGS: Relightable 3D Gaussian Splatting under Dynamic Illumination for Robotic Perception
arXiv:2608.14713v1 Announce Type: new Abstract: Robots operating in dark or poorly lit environments rely on onboard lights, which often produce uneven illumination that degrades downstream perception tasks. Prior approaches based on 2D image enhancement lack reliable supervision and fail to preserve multi-view geometric consistency. To address these limitations, we extend Dark Gaussian Splatting (DarkGS) toward a more accurate and flexible relightable 3D reconstruction framework. First, we eliminate the need for explicit light parameter calibration by jointly optimizing lighting parameters within the Gaussian Splatting framework. Second, we introduce a low-frequency illumination model based on spherical harmonics (SH) to capture spatially varying residual and ambient lighting effects. Third, we incorporate an MLP-based Bidirectional Reflectance Distribution Function (BRDF) to model non-Lambertian reflectance. Experiments on synthetic and real-world datasets demonstrate that our method